ADAM7 gene

ADAM metallopeptidase domain 7

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

From UniProt:

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.

From UniProt:

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Cytogenetic Location: 8p21.2, which is the short (p) arm of chromosome 8 at position 21.2

Molecular Location: base pairs 24,440,996 to 24,509,565 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p21.2, which is the short (p) arm of chromosome 8 at position 21.2
  • ADAM 7
  • ADAM-7
  • EAPI
  • GP-83
  • GP83