ADAM22 gene

ADAM metallopeptidase domain 22

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

From UniProt:

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

From NCBI Gene:

  • Early infantile epileptic encephalopathy 61

Cytogenetic Location: 7q21.12, which is the long (q) arm of chromosome 7 at position 21.12

Molecular Location: base pairs 87,934,143 to 88,202,889 on chromosome 7 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 7q21.12, which is the long (q) arm of chromosome 7 at position 21.12
  • ADAM 22
  • EIEE61
  • MDC2