2-methylbutyryl-CoA dehydrogenase deficiency
2-methylbutyryl-CoA dehydrogenase deficiency is a rare disorder in which the body is unable to process proteins properly. Normally, the body breaks down proteins from food into smaller parts called amino acids. Amino acids can be further processed to provide energy for the body. People with 2-methylbutyryl-CoA dehydrogenase deficiency cannot process a particular amino acid called isoleucine.
Most cases of 2-methylbutyryl-CoA dehydrogenase deficiency are detected shortly after birth by newborn screening, which identifies abnormal levels of certain compounds in the blood. In individuals with this condition, a compound called 2-methylbutyryl carnitine is elevated in the blood and another called 2-methylbutyrylglycine is elevated in the urine (2-methylbutyrylglycinuria).
Most people with 2-methylbutyryl-CoA dehydrogenase deficiency have no health problems related to the disorder. A small percentage of affected individuals develop signs and symptoms of the condition, which can begin soon after birth or later in childhood. The initial symptoms often include poor feeding, lack of energy (lethargy), vomiting, and irritability. These symptoms sometimes progress to serious health problems such as difficulty breathing, seizures, and coma. Additional problems can include poor growth, vision impairment, learning disabilities, muscle weakness, and delays in motor skills such as standing and walking.
It is unclear why some people with 2-methylbutyryl-CoA dehydrogenase deficiency develop health problems and others do not. Doctors suggest that in some cases, signs and symptoms may be triggered by infections, prolonged periods without food (fasting), or an increased amount of protein-rich foods in the diet.
2-methylbutyryl-CoA dehydrogenase deficiency is a rare condition; its worldwide prevalence is unknown. This condition is most common among Hmong populations in Southeast Asia and in people of Hmong descent, affecting 1 in 250 to 1 in 500 people in these communities. These individuals do not usually develop health problems related to the condition.
Mutations in the ACADSB gene cause 2-methylbutyryl-CoA dehydrogenase deficiency. This gene provides instructions for making an enzyme called 2-methylbutyryl-CoA dehydrogenase, which performs a chemical reaction that helps process the amino acid isoleucine. Mutations in the ACADSB gene reduce or eliminate the activity of this enzyme. With a shortage (deficiency) of 2-methylbutyryl-CoA dehydrogenase activity, the body is unable to break down isoleucine properly. Researchers speculate that some features of this disorder, such as lethargy and muscle weakness, occur because isoleucine is not converted to energy. In addition, impairment of 2-methylbutyryl-CoA dehydrogenase may allow the buildup of toxic compounds, which can lead to serious health problems.
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
These resources address the diagnosis or management of 2-methylbutyryl-CoA dehydrogenase deficiency:
These resources from MedlinePlus offer information about the diagnosis and management of various health conditions:
- 2-MBCD deficiency
- 2-methylbutyryl-coenzyme A dehydrogenase deficiency
- 2-methylbutyryl glycinuria
- short/branched-chain acyl-CoA dehydrogenase deficiency