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X-linked dominant

Definition(s)

Describes a dominant trait or disorder caused by a mutation in a gene on the X chromosome. The phenotype is expressed in heterozygous females as well as in hemizygous males (having only one X chromosome); affected males tend to have a more severe phenotype than affected females.

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Definition from: GeneTests from the University of Washington and Children's Health System, Seattle

Related discussion in the Handbook

X-Linked dominant (affected father)
X-Linked dominant (affected mother)
If a genetic disorder runs in my family, what are the chances that my children will have the condition?
What are the different ways in which a genetic condition can be inherited?


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