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Nucleotide excision repair

Synonym(s)

  • NER

Definition(s)

In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation and chemicals.

Definition from: Gene Ontology via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.

Definition from: NCI Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

See also Understanding Medical Terminology.

 
Published: November 24, 2014