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One gene interferes with or prevents the expression of another gene located at a different locus.

Definition from: Human Genome Project InformationThis link leads to a site outside Genetics Home Reference. at the U.S. Department of Energy

Epistasis is a circumstance where the expression of one gene is affected by the expression of one or more independently inherited genes. For example, if the expression of gene #2 depends on the expression of gene #1, but gene #1 becomes inactive, then the expression of gene #2 will not occur. In this example, gene #1 is said to be epistatic to gene #2.

Definition from: Talking Glossary of Genetic TermsThis link leads to a site outside Genetics Home Reference. from the National Human Genome Research Institute

See also Understanding Medical Terminology.

Published: November 30, 2015