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DNA repair

Synonym(s)

  • deoxyribonucleic acid repair

Definition(s)

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Definition from: MeSH via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Related discussion in the Handbook

See also Understanding Medical Terminology.

 
Published: October 9, 2014