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Basement membrane

Synonym(s)

  • basement membrane of connective tissue
  • basement membranes
  • membrana basalis

Definition(s)

A darkly stained mat-like extracellular matrix (ECM) that separates cell layers, such as epithelium from endothelium or a layer of connective tissue. The ECM layer that supports an overlying epithelium or endothelium is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of type IV collagen; glycoprotein laminin; and proteoglycan, provides barriers as well as channels between interacting cell layers.

Definition from: MeSH via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Ubiquitous supportive tissue adjacent to epithelium and around smooth and striated muscle cells. This tissue contains intrinsic macromolecular components such as collagen, laminin, and sulfated proteoglycans. As seen by light microscopy one of its subdivisions is the basal (basement) lamina.

Definition from: NCI via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Extracellular matrix characteristically found under epithelial cells.

Definition from: CRISP Thesaurus via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

See also Understanding Medical Terminology.

 
Published: March 23, 2015