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Allelic variant of unknown significance

Synonym(s)

An alteration in the normal sequence of a gene, the significance of which is unclear until further study of the genotype and corresponding phenotype in a sufficiently large population; complete gene sequencing often identifies numerous (sometimes hundreds) allelic variants for a given gene.: Definition from: GeneTests from the University of Washington and the National Center for Biotechnology Information
A variation in a genetic sequence whose association with disease risk is unknown. Also called variant of uncertain significance, unclassified variant, and VUS.: Definition from: National Cancer Institute dictionary


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