- unclassified variant
- variant of uncertain significance
- An alteration in the normal sequence of a gene, the significance of which is unclear until further study of the genotype and corresponding phenotype in a sufficiently large population; complete gene sequencing often identifies numerous (sometimes hundreds) allelic variants for a given gene.
Definition from: GeneReviews
from the University of Washington and the National Center for Biotechnology Information
- A variation in a genetic sequence whose association with disease risk is unknown. Also called variant of uncertain significance, unclassified variant, and VUS.
National Cancer Institute
Related discussion in the Handbook
See also Understanding Medical Terminology.