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Fluorescent in situ hybridization

Synonym(s)

Fluorescence in situ hybridization (FISH) is a laboratory technique for detecting and locating a specific DNA sequence on a chromosome. The technique relies on exposing chromosomes to a small DNA sequence called a probe that has a fluorescent molecule attached to it. The probe sequence binds to its corresponding sequence on the chromosome.: Definition from: Talking Glossary of Genetic Terms from the National Human Genome Research Institute
A physical mapping approach that uses fluorescein tags to detect hybridization of probes with metaphase chromosomes and with the less-condensed somatic interphase chromatin.: Definition from: Human Genome Project Information at the U.S. Department of Energy


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