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ZMYM gene family

Reviewed July 2013

What are the ZMYM genes?

Genes in the ZMYM family provide instructions for making proteins known as MYM-type zinc finger proteins. This family is a subset of a much larger group of zinc finger proteins, which are involved in many cellular functions.

Zinc finger proteins contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). This configuration makes zinc finger proteins very stable and enables them to attach (bind) firmly to other molecules.

Little is known about the function of MYM-type zinc finger proteins. Unlike many other zinc finger proteins, proteins in this family do not appear to bind to DNA. Instead, studies suggest that they help regulate interactions between other proteins. As part of protein complexes, MYM-type zinc finger proteins may be involved in regulating the activity of particular genes or repairing damaged DNA.

Which genes are included in the ZMYM gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of this member of the ZMYM gene family: ZMYM2.

What conditions are related to genes in the ZMYM gene family?

Genetics Home Reference includes these conditions related to genes in the ZMYM gene family:

Where can I find additional information about the ZMYM gene family?

You may find the following resources about the ZMYM gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the ZMYM gene family?

acids ; DNA ; ions ; protein

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (5 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: July 2013
Published: February 8, 2016