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ZCCHC gene family

Reviewed October 2010

What are the ZCCHC genes?

Genes in the ZCCHC family provide instructions for making proteins known as CCHC-containing zinc finger proteins. This family is a subset of a much larger group of zinc finger proteins, which are involved in many cellular functions.

Zinc finger proteins each contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). CCHC refers to the particular sequence of the amino acids cysteine and histidine found in proteins in the ZCCHC family. These amino acids fold around a single zinc ion, making the protein very stable and enabling it to attach (bind) firmly to other molecules.

Little is known about the function of CCHC-containing zinc finger proteins. Unlike many other zinc finger proteins, most proteins in this family do not appear to bind to DNA. Instead, studies suggest that they may help regulate interactions between other proteins.

Which genes are included in the ZCCHC gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of this member of the ZCCHC gene family: CNBP.

What conditions are related to genes in the ZCCHC gene family?

Genetics Home Reference includes these conditions related to genes in the ZCCHC gene family:

Where can I find additional information about the ZCCHC gene family?

You may find the following resources about the ZCCHC gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the ZCCHC gene family?

acids ; cysteine ; DNA ; domain ; histidine ; ions ; nucleic acid ; protein

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (3 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: October 2010
Published: February 1, 2016