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Genes in the tumor necrosis factor receptor superfamily (TNFRSF) provide instructions for making proteins that are involved in a variety of cellular functions. TNFRSF proteins are receptors that span the cell membrane, so that one end of the protein projects from the outer surface of the cell and the other end remains inside the cell. This structure allows the receptors to relay chemical signals from outside the cell to the interior of the cell.
Receptors in the TNFRSF family attach (bind) to a group of proteins known as tumor necrosis factors (TNFs) on the surface of cells. This binding triggers a series of chemical signals that can instruct cells to grow and divide, self-destruct (undergo apoptosis), or mature and take on specialized functions. TNFRSF receptors are found primarily on immune system cells, where they act as critical regulators of the body's immune responses and inflammatory reactions. These receptors also play important roles in the formation of tissues and organs during embryonic development (organogenesis). The receptors produced from two particular genes in this family, TNFRSF11A and TNFRSF11B, are involved in bone remodeling, the normal process by which old bone is broken down and new bone is created to replace it.
Studies suggest that changes in TNFRSF genes are associated with some autoimmune and chronic inflammatory diseases, such as lupus and rheumatoid arthritis. Mutations in the TNFRSF11A and TNFRSF11B genes are responsible for several rare bone diseases characterized by abnormal bone remodeling.
The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene families (http://www.genenames.org/cgi-bin/genefamilies/) and their member genes.
Genetics Home Reference summarizes the normal function and health implications of these members of the TNFRSF gene family: FAS, TNFRSF1A, TNFRSF11A, TNFRSF11B, and TNFRSF13B.
Genetics Home Reference includes these conditions related to genes in the TNFRSF gene family:
You may find the following resources about the TNFRSF gene family helpful.
apoptosis ; arthritis ; autoimmune ; bone remodeling ; cell ; cell membrane ; chronic ; domain ; embryonic ; FAS ; immune system ; necrosis ; osteoclast ; protein ; receptor ; transmembrane ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
These sources were used to develop the Genetics Home Reference summary for the TNFRSF gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.