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The THAP domain containing family includes genes that provide instructions for proteins that contain a region called a THAP domain. The THAP domain is a type of zinc finger domain, which are regions that include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions). This configuration makes proteins containing these domains very stable and enables them to attach (bind) firmly to other molecules.
Proteins in the THAP domain containing family target and bind to particular sequences of DNA building blocks (nucleotides). By binding to particular regions of DNA, THAP proteins act as transcription factors, which means they regulate the activity of other genes. In doing so, they play roles in cellular processes such as growth and division (proliferation), replication (the cell cycle), and controlled cell death (apoptosis). In addition, some proteins in this family are involved in the formation of blood vessels (angiogenesis).
Genetic changes that affect proteins produced from genes in this family have been linked to cancer and movement problems. The variety of these proteins' roles suggests that they might also be involved in additional types of disorders.
The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene families (http://www.genenames.org/cgi-bin/genefamilies/) and their member genes.
Genetics Home Reference summarizes the normal function and health implications of this member of the THAP domain containing gene family: THAP1.
Genetics Home Reference includes these conditions related to genes in the THAP domain containing gene family:
You may find the following resources about the THAP domain containing gene family helpful.
acids ; angiogenesis ; apoptosis ; cancer ; cell ; cell cycle ; DNA ; domain ; ions ; proliferation ; protein ; transcription ; zinc finger domain
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
These sources were used to develop the Genetics Home Reference summary for the THAP domain containing gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.