|A service of the U.S. National Library of Medicine®|
Sulfotransferases, membrane-bound gene family
Reviewed October 2012
What are the sulfotransferases, membrane-bound genes?
Genes in this family provide instructions for making enzymes called membrane-bound sulfotransferases. These enzymes carry out a process known as sulfation, in which a chemical group called a sulfate is transferred from one chemical compound to another. Most sulfotransferases get sulfates from a donor molecule called 3'-phosphoadenyl-5'-phosphosulfate (PAPS). The enzymes then add the sulfate to a variety of other protein, carbohydrate, and fat (lipid) molecules. Little is known about the molecules that are sulfated by these enzymes, although they probably play important roles in cell growth, signaling within cells, and protein-protein interactions.
Sulfotransferases in this family are described as membrane-bound because they are located in the membrane of a cell structure called the Golgi apparatus. The main function of this structure is to modify newly produced proteins.
Only a few human diseases have been associated with mutations in membrane-bound sulfotransferase genes. For example, CHST3 gene mutations cause a form of skeletal dysplasia characterized by progressive bone and joint abnormalities. Mutations in other membrane-bound sulfotransferase genes can cause abnormalities of the clear front covering of the eye (the cornea), chronic inflammation, and disorders of connective tissue (which normally supports the body's joints and organs).
Which genes are included in the sulfotransferases, membrane-bound gene family?
The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene
Genetics Home Reference summarizes the normal function and health implications of this member of the sulfotransferases, membrane-bound gene family: CHST3.
What conditions are related to genes in the sulfotransferases, membrane-bound gene family?
Genetics Home Reference includes these conditions related to genes in the sulfotransferases, membrane-bound gene family:
Where can I find additional information about the sulfotransferases, membrane-bound gene family?
You may find the following resources about the sulfotransferases, membrane-bound gene family helpful.
Where can I find general information about genes and gene families?
The Handbook provides basic information about genetics in clear language.
What glossary definitions help with understanding the sulfotransferases, membrane-bound gene family?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.