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ST3G gene family

Reviewed July 2014

What are the ST3G genes?

Genes in the ST3G family provide instructions for making enzymes called sialyltransferases. Within cells, these enzymes are located in the Golgi apparatus, which is a structure where newly produced proteins are modified. Sialyltransferases attach molecules called sialic acids to the ends of more complex molecules called glycoproteins and glycolipids, which consist of sugar molecules attached to certain proteins and fats (lipids). The addition of sialic acids influences a wide variety of cellular functions including cell movement (migration), attaching cells to one another (adhesion), signaling between cells, and inflammation. Molecules with attached sialic acids have diverse functions in the body, including roles in brain development, immune system function, and the spread (metastasis) of cancers.

Researchers have discovered at least 18 ST3G genes in humans. The enzyme produced from each gene adds sialic acids to one or more specific molecules. Mutations in the ST3GAL5 gene cause GM3 synthase deficiency, a condition characterized by recurrent seizures (epilepsy) and problems with brain development.

Which genes are included in the ST3G gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of this member of the ST3G gene family: ST3GAL5.

What conditions are related to genes in the ST3G gene family?

Genetics Home Reference includes these conditions related to genes in the ST3G gene family:

Where can I find additional information about the ST3G gene family?

You may find the following resources about the ST3G gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the ST3G gene family?

acids ; cell ; deficiency ; enzyme ; epilepsy ; gene ; glycolipids ; glycoproteins ; Golgi apparatus ; immune system ; inflammation ; metastasis

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (7 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: July 2014
Published: February 8, 2016