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RAB gene family

Reviewed January 2010

What are the RAB genes?

Genes in the RAB family provide instructions for making proteins that are involved in a process called vesicle trafficking, which moves materials within cells in sac-like structures called vesicles. Some vesicles are formed when the cell membrane folds around a substance outside the cell. The vesicle is drawn into the cell and is pinched off from the cell membrane. This method of bringing substances into cells is called endocytosis.

Vesicles may also be formed from the membranes of other structures within the cell, such as the endoplasmic reticulum or the Golgi apparatus. Vesicles transport many types of molecules from the interior of the cell to its surface, where they may attach and interact with other substances, or be secreted by the cell.

RAB proteins are GTPases, which means they convert a molecule called GTP into another molecule called GDP. The RAB protein acts like a switch, and it is turned on and off by GTP and GDP molecules. The protein must be turned on (activated) by attaching (binding) to GTP, and it is turned off (inactivated) when it converts GTP to GDP. Only the active protein can bind to other proteins called Rab effectors, which help move vesicles to their proper destination. This switching function helps regulate vesicle trafficking in the nervous system and other tissues.

Which genes are included in the RAB gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the RAB familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference summarizes the normal function and health implications of these members of the RAB gene family: RAB7A, RAB23, and RAB27A.

What conditions are related to genes in the RAB gene family?

Genetics Home Reference includes these conditions related to genes in the RAB gene family:

Where can I find additional information about the RAB gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the RAB gene family?

cell ; cell membrane ; endocytosis ; endoplasmic reticulum ; Golgi apparatus ; GTP ; molecule ; nervous system ; oncogene ; protein ; RAS ; RAS oncogene ; vesicle

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (3 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: January 2010
Published: March 30, 2015