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Mitochondrial respiratory chain complex assembly factors

Mitochondrial respiratory chain complex assembly factors gene family

Reviewed April 2014

What are the mitochondrial respiratory chain complex assembly factors genes?

The mitochondrial respiratory chain complex assembly factors gene family contains genes that provide instructions for making proteins involved in oxidative phosphorylation (also known as the respiratory chain). Oxidative phosphorylation is an important cellular process that uses oxygen and simple sugars to create adenosine triphosphate (ATP), the cell's main energy source. Five protein complexes, each made up of several proteins, carry out this process. To form these complexes, proteins must be added in a coordinated way. Proteins produced from genes in the mitochondrial respiratory chain complex assembly factors gene family help put together the protein complexes involved in oxidative phosphorylation.

Mutations in genes in this family can impair the formation of one or more of the protein complexes, disrupting oxidative phosphorylation. Researchers believe that impaired oxidative phosphorylation can lead to cell death by reducing the amount of energy available in the cell. The resulting damage to organs and tissues in the body can lead to a variety of conditions, such as Leigh syndrome and mitochondrial complex III deficiency.

Which genes are included in the mitochondrial respiratory chain complex assembly factors gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of these members of the mitochondrial respiratory chain complex assembly factors gene family: BCS1L, SDHAF2, and SURF1.

What conditions are related to genes in the mitochondrial respiratory chain complex assembly factors gene family?

Genetics Home Reference includes these conditions related to genes in the mitochondrial respiratory chain complex assembly factors gene family:

Where can I find additional information about the mitochondrial respiratory chain complex assembly factors gene family?

You may find the following resources about the mitochondrial respiratory chain complex assembly factors gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the mitochondrial respiratory chain complex assembly factors gene family?

adenosine triphosphate ; ATP ; cell ; deficiency ; dehydrogenase ; gene ; oxidative phosphorylation ; oxygen ; phosphorylation ; protein ; respiratory ; syndrome ; synthesis

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (5 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: April 2014
Published: May 25, 2015