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Immunoglobulin superfamily, immunoglobulin-like domain containing gene family
Reviewed October 2013
What are the immunoglobulin superfamily, immunoglobulin-like domain containing genes?
The immunoglobulin-like domain containing gene family is a subset of the immunoglobulin superfamily. Genes in the immunoglobulin superfamily provide instructions for making proteins that have a certain region called an immunoglobulin-like (Ig-like) domain. The domain is described as Ig-like because it resembles regions found in molecules called antibodies (also known as immunoglobulins). Antibodies are specialized proteins that attach (bind) to foreign invaders, such as bacteria and viruses, as part of the body's immune response.
Antibodies contain a variable (V) region and a constant (C) region. Ig-like domains can resemble either the variable region or the constant region; these domains are described as V-set and C-set, respectively. Some Ig-like domains have characteristics of both the variable and constant regions; these domains are described as I-set, meaning intermediate. Genes that provide instructions for proteins with an Ig-like domain that does not fit into the previous categories are assigned to the immunoglobulin-like domain containing family.
Much like the role of antibodies in recognizing and binding particular substances, the Ig-like domain allows proteins to interact with other molecules. Many Ig-like domain containing proteins act as receptors that bind other proteins referred to as their ligands. This binding stimulates signaling inside the cell that helps the cell respond to its environment. Other proteins with this domain are found in muscle cells; their ability to bind other muscle proteins aid in muscle tensing (contraction). Because the proteins produced from genes in the Ig-like domain containing family have such diverse functions, changes in these genes can cause a variety of disorders that affect different body systems.
Which genes are included in the immunoglobulin superfamily, immunoglobulin-like domain containing gene family?
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the immunoglobulin superfamily, immunoglobulin-like domain containing
Genetics Home Reference summarizes the normal function and health implications of these members of the immunoglobulin superfamily, immunoglobulin-like domain containing gene family: FLT3, FLT4, KIT, LEPR, NTRK1, PDGFRB, ROBO3, TEK, and TTN.
What conditions are related to genes in the immunoglobulin superfamily, immunoglobulin-like domain containing gene family?
Genetics Home Reference includes these conditions related to genes in the immunoglobulin superfamily, immunoglobulin-like domain containing gene family:
Where can I find general information about genes and gene families?
The Handbook provides basic information about genetics in clear language.
What glossary definitions help with understanding the immunoglobulin superfamily, immunoglobulin-like domain containing gene family?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.