Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions About   Site Map   Contact Us
Home A service of the U.S. National Library of Medicine®

FOX gene family

Reviewed December 2013

What are the FOX genes?

The FOX gene family provides instructions for making proteins that play a critical role in the formation of many organs and tissues before birth. These proteins are transcription factors, which means that they attach (bind) to specific regions of DNA and help control the activity of many other genes. Members of the FOX family are involved in many aspects of embryonic development. FOX proteins regulate certain gene activities in the eyes, lungs, brain, cardiovascular system, digestion system, immune system, and cell division cycle. Mutations in some FOX genes can lead to tumor development.

The FOX genes are named with a letter and a number in order to identify which FOX gene subfamily they belong to. The subfamilies are designated by a letter (A through R) and the individual genes in these subfamilies are further designated by a number (e.g. FOXD4).

Which genes are included in the FOX gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of these members of the FOX gene family: FOXC1, FOXC2, FOXF1, FOXG1, FOXL2, FOXN1, and FOXP3.

What conditions are related to genes in the FOX gene family?

Where can I find additional information about the FOX gene family?

You may find the following resources about the FOX gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the FOX gene family?

cardiovascular ; cell ; cell division ; cell division cycle ; digestion ; DNA ; embryonic ; gene ; immune system ; motif ; transcription ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (7 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: December 2013
Published: February 8, 2016