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Genes in this family provide instructions for making specialized proteins called endogenous ligands. A ligand is a protein that attaches (binds) to another protein called a receptor; receptor proteins have specific sites into which the ligands fit like keys into locks. Endogenous ligands are those that are produced in the body, not those introduced into the body, such as certain drugs.
Together, ligands and their receptors trigger signals that affect cell development and function. Alterations in ligands can impair cell signaling and change the normal activities of cells. Because ligands mediate many different functions in the body, mutations in genes in the endogenous ligands gene family can have a variety of effects.
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the endogenous ligands family (http://www.genenames.org/genefamilies/ENDOLIG).
Genetics Home Reference summarizes the normal function and health implications of these members of the endogenous ligands gene family: AGT, AMH, APP, AVP, BDNF, C3, EDN3, F2, FGA, FGB, FGG, GDF3, GH1, HTT, IL1A, NDP, NGF, POMC, PROC, PROK2, PSAP, RB1, SAA1, TGFB1, TGFB2, THPO, TSHB, VWF, WNT3, and WNT4.
Genetics Home Reference includes these conditions related to genes in the endogenous ligands gene family:
amyloid ; arginine ; cell ; coagulation ; coagulation factors ; differentiation ; fibrinogen ; gene ; growth factor ; growth hormone ; hormone ; ligand ; mediate ; precursor ; protein ; pseudoglioma ; receptor ; thrombin ; thyroid
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
These sources were used to develop the Genetics Home Reference summary for the endogenous ligands gene family.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.