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Endogenous ligands gene family

Reviewed May 2013

What are the endogenous ligands genes?

Genes in this family provide instructions for making specialized proteins called endogenous ligands. A ligand is a protein that attaches (binds) to another protein called a receptor; receptor proteins have specific sites into which the ligands fit like keys into locks. Endogenous ligands are those that are produced in the body, not those introduced into the body, such as certain drugs.

Together, ligands and their receptors trigger signals that affect cell development and function. Alterations in ligands can impair cell signaling and change the normal activities of cells. Because ligands mediate many different functions in the body, mutations in genes in the endogenous ligands gene family can have a variety of effects.

Which genes are included in the endogenous ligands gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of these members of the endogenous ligands gene family: AGT, AMH, APP, AVP, BDNF, C3, EDN3, F2, FGA, FGB, FGG, FN1, GDF3, GH1, HTT, IL1A, NDP, NGF, POMC, PROC, PROK2, PSAP, RB1, SAA1, TGFB1, TGFB2, THPO, TSHB, VWF, WNT3, WNT4, and WNT5A.

What conditions are related to genes in the endogenous ligands gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the endogenous ligands gene family?

amyloid ; arginine ; cell ; coagulation ; coagulation factors ; differentiation ; fibrinogen ; gene ; growth factor ; growth hormone ; hormone ; ligand ; mediate ; precursor ; protein ; pseudoglioma ; receptor ; thrombin ; thyroid

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (4 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: May 2013
Published: February 1, 2016