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CD gene family

Reviewed February 2012

What are the CD genes?

The CD genes belong to a large family of genes called the cluster of differentiation. Many CD genes provide instructions for making proteins that are found on the surface of white blood cells (leukocytes) at various stages of their development. These proteins help the white blood cells interact with the body's tissues and attack bacteria, viruses, and other invaders.

Other members of the CD gene family work outside of the immune system. For example, some CD genes play a role in cell signaling and the development of the nervous system.

Most of the genes in this family are designated by the letters CD and a number corresponding to the specific gene within the family, such as CD132. Many of the genes in the CD gene family also have other names that may be more commonly used. For example, the CD132 gene is also called IL2RG.

Which genes are included in the CD gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides an index of gene familiesThis link leads to a site outside Genetics Home Reference. and their member genes.

Genetics Home Reference summarizes the normal function and health implications of these members of the CD gene family: ACE, ALK, BMPR1A, CD40LG, CDH1, CSF1R, CXCR4, ENG, FAS, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FZD4, IL2RG, IL7R, ITGA2B, ITGA6, ITGB2, ITGB3, ITGB4, JAG1, KIT, L1CAM, LAMP2, MPL, MUC1, PDGFRA, PRNP, SLC4A1, TNFRSF1A, TNFRSF11A, and TNFRSF13B.

What conditions are related to genes in the CD gene family?

Genetics Home Reference includes these conditions related to genes in the CD gene family:

Where can I find additional information about the CD gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the CD gene family?

adhesion molecule ; anion ; antigens ; bacteria ; carrier ; cell ; cell adhesion ; class ; differentiation ; enzyme ; FAS ; fibroblast ; gene ; growth factor ; immune system ; kinase ; ligand ; lymphoma ; molecule ; motif ; necrosis ; nervous system ; oncogene ; prion ; protein ; proto-oncogene ; receptor ; sarcoma ; solute ; tumor ; tyrosine ; white blood cells

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (2 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: February 2012
Published: November 23, 2015