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ADAMTS gene family
Reviewed October 2008
What are the ADAMTS genes?
The ADAMTS gene family provides instructions for making a group of enzymes with a wide variety of functions. These enzymes are described as metalloproteases, which means that they contain a metal (in this case, zinc) and have protease activity (that is, they cut apart other proteins).
The human ADAMTS gene family consists of 19 related genes. These genes are designated ADAMTS1 through ADAMTS20. (There is no ADAMTS11 gene; this gene was found to be the same as ADAMTS5.)
Enzymes in the ADAMTS family are involved in many different processes in cells and tissues. They play roles in attaching cells together (cell adhesion), the movement (migration) of cells, blood clotting (coagulation), inflammation, and the formation of new blood vessels (angiogenesis). ADAMTS enzymes are also critical for the normal structure and function of connective tissue, which forms the body's supportive framework. Several ADAMTS enzymes are active before birth; they are probably involved in the formation and development of the body's organs and tissues.
Changes in ADAMTS genes have been associated with several diseases, including connective tissue disorders (such as Ehlers-Danlos syndrome), osteoarthritis, and a blood clotting disorder called thrombotic thrombocytopenic purpura. Studies suggest that abnormal regulation of enzymes in the ADAMTS family may also play a role in several types of cancer.
Which genes are included in the ADAMTS gene family?
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the ADAMTS
What conditions are related to genes in the ADAMTS gene family?
Genetics Home Reference includes these conditions related to genes in the ADAMTS gene family:
Where can I find additional information about the ADAMTS gene family?
You may find the following resources about the ADAMTS gene family helpful.
Where can I find general information about genes and gene families?
The Handbook provides basic information about genetics in clear language.
What glossary definitions help with understanding the ADAMTS gene family?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.