|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed July 2010
What is the official name of the TREX1 gene?
The official name of this gene is “three prime repair exonuclease 1.”
TREX1 is the gene's official symbol. The TREX1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TREX1 gene?
The TREX1 gene provides instructions for making the 3-prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends of the molecules. In this way, it breaks down unneeded DNA molecules or fragments that may be generated during copying (replication) of cells' genetic material in preparation for cell division, DNA repair, cell death, and other processes.
How are changes in the TREX1 gene related to health conditions?
Genetics Home Reference provides information about systemic lupus erythematosus, which is also associated with changes in the TREX1 gene.
Where is the TREX1 gene located?
Cytogenetic Location: 3p21.31
Molecular Location on chromosome 3: base pairs 48,465,520 to 48,467,645
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TREX1 gene is located on the short (p) arm of chromosome 3 at position 21.31.
More precisely, the TREX1 gene is located from base pair 48,465,520 to base pair 48,467,645 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TREX1?
You and your healthcare professional may find the following resources about TREX1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TREX1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TREX1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.