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Reviewed September 2009
What is the official name of the SEPT9 gene?
The official name of this gene is “septin 9.”
SEPT9 is the gene's official symbol. The SEPT9 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SEPT9 gene?
The SEPT9 gene provides instructions for making a protein called septin-9, which is part of a group of proteins called septins. Septins are involved in a process called cytokinesis, which is the step in cell division when the fluid inside the cell (cytoplasm) divides to form two separate cells. The septin-9 protein also seems to act as a tumor suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or in an uncontrolled way.
The SEPT9 gene seems to be turned on (active) in cells throughout the body. Approximately 15 slightly different versions (isoforms) of the septin-9 protein may be produced from this gene. Some types of cells make certain isoforms, while other cell types produce other isoforms. However, the specific distribution of these isoforms in the body's tissues is not well understood. Septin-9 isoforms interact with other septin proteins to perform some of their functions.
How are changes in the SEPT9 gene related to health conditions?
Where is the SEPT9 gene located?
Cytogenetic Location: 17q25
Molecular Location on chromosome 17: base pairs 77,281,409 to 77,500,595
The SEPT9 gene is located on the long (q) arm of chromosome 17 at position 25.
More precisely, the SEPT9 gene is located from base pair 77,281,409 to base pair 77,500,595 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SEPT9?
You and your healthcare professional may find the following resources about SEPT9 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SEPT9 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SEPT9?
acids ; amino acid ; angiogenesis ; arginine ; autoimmune ; cancer ; cell ; cell division ; cytokinesis ; cytoplasm ; duplication ; esophagus ; gene ; gene expression ; immune system ; isoforms ; kidney ; mutation ; ovarian ; ovary ; pancreas ; proliferation ; prostate ; protein ; protein sequence ; thyroid ; tryptophan ; tumor ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.