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Reviewed September 2009
What is the official name of the ITGB4 gene?
The official name of this gene is “integrin, beta 4.”
ITGB4 is the gene's official symbol. The ITGB4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ITGB4 gene?
The ITGB4 gene provides instructions for making one part (the β4 subunit) of a protein known as an integrin. Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes.
The integrin protein made with the β4 subunit is known as α6β4 integrin. This protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. The α6β4 integrin protein plays a particularly important role in strengthening and stabilizing the skin. It is a component of hemidesmosomes, which are microscopic structures that anchor the outer layer of the skin (the epidermis) to underlying layers. As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together.
Does the ITGB4 gene share characteristics with other genes?
The ITGB4 gene belongs to a family of genes called CD (CD molecules). It also belongs to a family of genes called fibronectin type III domain containing (fibronectin type III domain containing). It also belongs to a family of genes called ITG (integrins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ITGB4 gene related to health conditions?
Where is the ITGB4 gene located?
Cytogenetic Location: 17q25
Molecular Location on chromosome 17: base pairs 75,721,341 to 75,757,818
The ITGB4 gene is located on the long (q) arm of chromosome 17 at position 25.
More precisely, the ITGB4 gene is located from base pair 75,721,341 to base pair 75,757,818 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ITGB4?
You and your healthcare professional may find the following resources about ITGB4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ITGB4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ITGB4?
apoptosis ; atresia ; basement membrane ; cancer ; cell ; cell adhesion ; colon ; digestive ; epidermis ; epithelial ; extracellular ; extracellular matrix ; gene ; growth factor ; integrins ; kinase ; lymphocyte ; obstruction ; oncogene ; progression ; protein ; pyloric ; receptor ; signal transduction ; subunit ; transduction ; transmembrane ; trauma ; vascular
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.