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Reviewed May 2012
What is the official name of the FLI1 gene?
The official name of this gene is “Fli-1 proto-oncogene, ETS transcription factor.”
FLI1 is the gene's official symbol. The FLI1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FLI1 gene?
The FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription. The FLI protein attaches (binds) to certain regions of DNA and turns on (activates) the transcription of nearby genes. The proteins produced from these genes control many important cellular processes, such as cell growth and division (proliferation), maturation (differentiation), and survival. The FLI protein is found primarily in blood cells and is thought to regulate their development.
How are changes in the FLI1 gene related to health conditions?
Genetics Home Reference provides information about Jacobsen syndrome, which is also associated with changes in the FLI1 gene.
Where is the FLI1 gene located?
Cytogenetic Location: 11q24.1-q24.3
Molecular Location on chromosome 11: base pairs 128,686,534 to 128,813,266
The FLI1 gene is located on the long (q) arm of chromosome 11 between positions 24.1 and 24.3.
More precisely, the FLI1 gene is located from base pair 128,686,534 to base pair 128,813,266 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FLI1?
You and your healthcare professional may find the following resources about FLI1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FLI1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FLI1?
cartilage ; cell ; chromosome ; differentiation ; DNA ; fusion gene ; gene ; inherited ; leukemia ; mutation ; oncogene ; peripheral ; proliferation ; protein ; proto-oncogene ; rearrangement ; sarcoma ; somatic mutation ; syndrome ; transcription ; transcription factor ; translocation ; tumor ; virus
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.