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Reviewed April 2014
What is the official name of the DNAI1 gene?
The official name of this gene is “dynein, axonemal, intermediate chain 1.”
DNAI1 is the gene's official symbol. The DNAI1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DNAI1 gene?
The DNAI1 gene provides instructions for making a protein that is part of a group (complex) of proteins called dynein. This complex functions within cell structures called cilia. Cilia are microscopic, finger-like projections that stick out from the surface of cells. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Dynein produces the force needed for cilia to move.
Within the core of cilia (the axoneme), dynein complexes are part of structures known as inner dynein arms (IDAs) and outer dynein arms (ODAs) depending on their location. Coordinated movement of the dynein arms causes the entire axoneme to bend back and forth. IDAs and ODAs have different combinations of protein components (subunits) that are classified by weight as heavy, intermediate, or light chains. The DNAI1 gene provides instructions for making intermediate chain 1, which is found in ODAs. Other subunits are produced from different genes.
Does the DNAI1 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the DNAI1 gene related to health conditions?
Where is the DNAI1 gene located?
Cytogenetic Location: 9p13.3
Molecular Location on chromosome 9: base pairs 34,458,751 to 34,520,988
The DNAI1 gene is located on the short (p) arm of chromosome 9 at position 13.3.
More precisely, the DNAI1 gene is located from base pair 34,458,751 to base pair 34,520,988 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DNAI1?
You and your healthcare professional may find the following resources about DNAI1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DNAI1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DNAI1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.