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Reviewed August 2012
What is the official name of the ANG gene?
The official name of this gene is “angiogenin, ribonuclease, RNase A family, 5.”
ANG is the gene's official symbol. The ANG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ANG gene?
The ANG gene provides instructions for making a protein called angiogenin. This protein promotes the formation of new blood vessels from pre-existing blood vessels through a process called angiogenesis. In this process, angiogenin helps stimulate the growth and division of endothelial cells, which line the inside surface of blood vessels, to form new blood vessels. Angiogenesis is important for restoring blood flow after an injury. Angiogenin may also be involved in other steps of angiogenesis, such as helping to break down the tissue that surrounds existing blood vessels to allow room for the growth of new blood vessels.
Angiogenin is found in a variety of cells throughout the body and circulates in the bloodstream. When angiogenin attaches (binds) to receptors on the surface of endothelial cells, it triggers a series of reactions that bring angiogenin inside the cell. Once inside endothelial cells, angiogenin moves to the nucleus where it plays a role in regulating protein production. To stimulate the production of proteins, angiogenin triggers the production of ribosomal RNA (rRNA), a chemical cousin of DNA. Ribosomal RNA is required for assembling protein building blocks (amino acids) into functioning proteins. Angiogenin triggers the production of rRNA when there is an increased demand for proteins, such as for the growth and division of endothelial cells. When proteins are not needed, angiogenin breaks down a form of RNA called transfer RNA (tRNA), which, along with rRNA, is needed for assembling amino acids into full-length, functioning proteins.
Research findings suggest that angiogenin also has antimicrobial properties, which means it can help fight infections caused by bacteria and fungi.
Does the ANG gene share characteristics with other genes?
The ANG gene belongs to a family of genes called RNASE (ribonucleases, RNase A).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ANG gene related to health conditions?
Where is the ANG gene located?
Cytogenetic Location: 14q11.1-q11.2
Molecular Location on chromosome 14: base pairs 21,152,335 to 21,162,344
The ANG gene is located on the long (q) arm of chromosome 14 between positions 11.1 and 11.2.
More precisely, the ANG gene is located from base pair 21,152,335 to base pair 21,162,344 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ANG?
You and your healthcare professional may find the following resources about ANG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ANG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ANG?
acids ; angiogenesis ; antimicrobial ; bacteria ; cell ; dementia ; DNA ; endothelial cells ; gene ; injury ; nucleus ; protein ; ribosomal RNA ; RNA ; sclerosis ; tissue ; transfer RNA ; tRNA ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.