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Reviewed August 2013
What is the official name of the ZMPSTE24 gene?
The official name of this gene is “zinc metallopeptidase STE24.”
ZMPSTE24 is the gene's official symbol. The ZMPSTE24 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ZMPSTE24 gene?
The ZMPSTE24 gene provides instructions for making a protein that acts as a protease, which is an enzyme that cuts (cleaves) other proteins. The ZMPSTE24 protein cuts an immature version of the lamin A protein (prelamin A) at a particular location; this cleavage is an essential step in the maturation of lamin A.
Mature lamin A is a component of the nuclear envelope, which is the membrane that surrounds the nucleus in cells. The nuclear envelope regulates the movement of molecules into and out of the nucleus, and researchers believe it may play a role in regulating the activity of certain genes.
How are changes in the ZMPSTE24 gene related to health conditions?
Where is the ZMPSTE24 gene located?
Cytogenetic Location: 1p34
Molecular Location on chromosome 1: base pairs 40,258,049 to 40,294,183
The ZMPSTE24 gene is located on the short (p) arm of chromosome 1 at position 34.
More precisely, the ZMPSTE24 gene is located from base pair 40,258,049 to base pair 40,294,183 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ZMPSTE24?
You and your healthcare professional may find the following resources about ZMPSTE24 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ZMPSTE24 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ZMPSTE24?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.