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The information on this page was automatically extracted from online scientific databases.

What is the official name of the ZIC1 gene?

The official name of this gene is “Zic family member 1.”

ZIC1 is the gene's official symbol. The ZIC1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the ZIC1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

How are changes in the ZIC1 gene related to health conditions?

Genetics Home Reference provides information about Dandy-Walker syndrome, which is associated with changes in the ZIC1 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
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Where is the ZIC1 gene located?

Cytogenetic Location: 3q24

Molecular Location on chromosome 3: base pairs 147,409,393 to 147,416,718

The ZIC1 gene is located on the long (q) arm of chromosome 3 at position 24.

The ZIC1 gene is located on the long (q) arm of chromosome 3 at position 24.

More precisely, the ZIC1 gene is located from base pair 147,409,393 to base pair 147,416,718 on chromosome 3.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about ZIC1?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the ZIC1 gene or gene products?

  • ZIC
  • ZNF201

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding ZIC1?

apolipoprotein ; cerebellum ; chromosome ; CNS ; consensus sequence ; cytoplasm ; gene ; medulloblastoma ; nucleus ; protein ; stage ; transcription ; transcription factor ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: September 29, 2014