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Reviewed April 2014
What is the official name of the ZFYVE26 gene?
The official name of this gene is “zinc finger, FYVE domain containing 26.”
ZFYVE26 is the gene's official symbol. The ZFYVE26 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ZFYVE26 gene?
The ZFYVE26 gene provides instructions for making a protein called spastizin, which is found in most tissues. Spastizin is important in a process called autophagy, in which worn-out cell parts and unneeded proteins are recycled within cells. Specifically, spastizin is involved in the formation and maturation of sacs called autophagosomes (or autophagic vacuoles). Autophagosomes surround materials that need to be recycled. The autophagosome then attaches (fuses) to a cell structure called a lysosome, which breaks down and recycles the materials.
In addition to being involved in clearing cells of unneeded materials, spastizin also plays a role in ensuring the proper division of cells. During the final stages of cell division, spastizin participates in the process by which the dividing cells separate from one another (cytokinesis).
Does the ZFYVE26 gene share characteristics with other genes?
The ZFYVE26 gene belongs to a family of genes called ZFYVE (zinc fingers, FYVE-type).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ZFYVE26 gene related to health conditions?
Where is the ZFYVE26 gene located?
Cytogenetic Location: 14q24.1
Molecular Location on chromosome 14: base pairs 67,729,569 to 67,816,611
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ZFYVE26 gene is located on the long (q) arm of chromosome 14 at position 24.1.
More precisely, the ZFYVE26 gene is located from base pair 67,729,569 to base pair 67,816,611 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ZFYVE26?
You and your healthcare professional may find the following resources about ZFYVE26 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ZFYVE26 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ZFYVE26?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.