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The official name of this gene is “zinc finger protein, FOG family member 2.”
ZFPM2 is the gene's official symbol. The ZFPM2 gene is also known by other names, listed below.
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
The disease may be caused by mutations affecting the gene represented in this entry.
The disease is caused by mutations affecting the gene represented in this entry.
|||610187 (http://omim.org/entry/610187)||DIAPHRAGMATIC HERNIA 3|
|||187500 (http://omim.org/entry/187500)||TETRALOGY OF FALLOT|
|603693 (http://omim.org/entry/603693)||ZINC FINGER PROTEIN, MULTITYPE 2|
Cytogenetic Location: 8q23
Molecular Location on chromosome 8: base pairs 106,330,916 to 106,816,766
The ZFPM2 gene is located on the long (q) arm of chromosome 8 at position 23.
More precisely, the ZFPM2 gene is located from base pair 106,330,916 to base pair 106,816,766 on chromosome 8.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about ZFPM2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
cell ; cofactor ; corepressor ; coronary ; differentiation ; expressed ; gene ; hernia ; mRNA ; promoter ; protein ; tetralogy of Fallot ; transcription
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.