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Reviewed February 2011
What is the official name of the ZFP57 gene?
The official name of this gene is “ZFP57 zinc finger protein.”
ZFP57 is the gene's official symbol. The ZFP57 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ZFP57 gene?
The protein produced from the ZFP57 gene is a member of a family called zinc finger proteins, which are involved in many cellular functions. Zinc finger proteins each contain one or more short regions called zinc finger domains. These regions include a specific pattern of protein building blocks (amino acids) and one or more charged atoms of zinc (zinc ions).
Zinc finger proteins attach (bind) primarily to DNA. In most cases, these proteins attach to regions near certain genes and turn the genes on and off as needed. Proteins that bind to DNA and regulate the activity of particular genes are known as transcription factors. Some zinc finger proteins can also bind to other molecules, including RNA (a chemical cousin of DNA) and proteins.
The ZFP57 protein is involved in the regulation of other genes by the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms (methylation). Methylation is important in many cellular functions. These include determining whether the instructions in a particular segment of DNA are carried out or suppressed (gene silencing), regulating reactions involving proteins and lipids, and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters).
How are changes in the ZFP57 gene related to health conditions?
Where is the ZFP57 gene located?
Cytogenetic Location: 6p22.1
Molecular Location on chromosome 6: base pairs 29,672,392 to 29,681,146
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ZFP57 gene is located on the short (p) arm of chromosome 6 at position 22.1.
More precisely, the ZFP57 gene is located from base pair 29,672,392 to base pair 29,681,146 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ZFP57?
You and your healthcare professional may find the following resources about ZFP57 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ZFP57 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ZFP57?
acids ; apoptosis ; atom ; chromosome ; diabetes ; diabetes mellitus ; DNA ; expressed ; gene ; gene silencing ; glucose ; imprinting ; inherit ; inherited ; insulin ; ions ; methyl ; methylation ; neonatal ; nervous system ; neurotransmitters ; protein ; RNA ; secretion ; transcription ; transient
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.