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Reviewed November 2009
What is the official name of the YWHAE gene?
The official name of this gene is “tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon.”
YWHAE is the gene's official symbol. The YWHAE gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the YWHAE gene?
The YWHAE gene provides instructions for making the 14-3-3 epsilon (ε) protein, which is part of the large 14-3-3 protein family. Proteins in this family attach (bind) to other proteins involved in cell signaling. 14-3-3 proteins either turn on (activate) or turn off (inactivate) these other proteins. The 14-3-3ε protein helps to regulate a variety of processes including cell division and sensitivity to insulin, a hormone that helps control blood sugar levels.
The 14-3-3ε protein is active in tissues throughout the body, although its function is sometimes unclear. In the brain, this protein is involved in directing the movement of nerve cells (neuronal migration) by binding to other proteins involved in this process. It is thought that the 14-3-3ε protein is critical for proper neuronal migration and normal brain development.
How are changes in the YWHAE gene related to health conditions?
Where is the YWHAE gene located?
Cytogenetic Location: 17p13.3
Molecular Location on chromosome 17: base pairs 1,344,540 to 1,400,375
The YWHAE gene is located on the short (p) arm of chromosome 17 at position 13.3.
More precisely, the YWHAE gene is located from base pair 1,344,540 to base pair 1,400,375 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about YWHAE?
You and your healthcare professional may find the following resources about YWHAE helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the YWHAE gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding YWHAE?
cell ; cell division ; chromosome ; deficiency ; deletion ; disability ; gene ; gene deletion ; hormone ; insulin ; kinase ; neuronal migration ; protein ; sensitivity ; short stature ; stature ; subunit ; syndrome ; tryptophan ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.