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Reviewed January 2010
What is the official name of the YARS gene?
The official name of this gene is “tyrosyl-tRNA synthetase.”
YARS is the gene's official symbol. The YARS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the YARS gene?
The YARS gene provides instructions for making an enzyme called tyrosyl-tRNA synthetase. This enzyme is found in all cells, where it plays an important role in the production (synthesis) of proteins. During protein synthesis, building blocks (amino acids) are connected together in a specific order, creating the chain of amino acids that makes up the protein. Tyrosyl-tRNA synthetase plays a role in adding the amino acid tyrosine at the proper place in a protein's chain of amino acids.
In addition to its role in protein synthesis, tyrosyl-tRNA synthetase appears to have other functions. Under certain conditions, such as inflammation, this enzyme is cut (cleaved) into two fragments called mini-tyrRS and C-tyrRS. Research indicates that mini-tyrRS promotes the growth of new blood vessels (angiogenesis). Both fragments appear to stimulate the movement of particular cells, such as white blood cells that help fight infection.
Does the YARS gene share characteristics with other genes?
The YARS gene belongs to a family of genes called aaRS (aminoacyl tRNA synthetases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the YARS gene related to health conditions?
Where is the YARS gene located?
Cytogenetic Location: 1p35.1
Molecular Location on chromosome 1: base pairs 32,775,239 to 32,818,032
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The YARS gene is located on the short (p) arm of chromosome 1 at position 35.1.
More precisely, the YARS gene is located from base pair 32,775,239 to base pair 32,818,032 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about YARS?
You and your healthcare professional may find the following resources about YARS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the YARS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding YARS?
acids ; amino acid ; angiogenesis ; arginine ; enzyme ; gene ; glutamic acid ; glycine ; infection ; inflammation ; ligase ; lysine ; mutation ; protein ; synthesis ; tRNA ; tyrosine ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.