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Reviewed May 2010
What is the official name of the XPC gene?
The official name of this gene is “xeroderma pigmentosum, complementation group C.”
XPC is the gene's official symbol. The XPC gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the XPC gene?
The XPC gene provides instructions for making a protein that is involved in repairing damaged DNA. DNA can be damaged by ultraviolet (UV) rays from the sun and by toxic chemicals, radiation, and unstable molecules called free radicals.
DNA damage occurs frequently, but normal cells are usually able to fix it before it can cause problems. One of the major mechanisms that cells use to fix DNA is known as nucleotide excision repair (NER). The XPC protein starts this repair process by detecting DNA damage. Then a group (complex) of other proteins unwind the section of DNA where the damage has occurred, snip out (excise) the abnormal section, and replace the damaged area with the correct DNA.
Studies suggest that the XPC protein may have additional roles in DNA repair and in other cell activities. Less is known about these proposed functions of the XPC protein.
How are changes in the XPC gene related to health conditions?
Where is the XPC gene located?
Cytogenetic Location: 3p25.1
Molecular Location on chromosome 3: base pairs 14,145,147 to 14,178,672
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The XPC gene is located on the short (p) arm of chromosome 3 at position 25.1.
More precisely, the XPC gene is located from base pair 14,145,147 to base pair 14,178,672 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about XPC?
You and your healthcare professional may find the following resources about XPC helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the XPC gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding XPC?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.