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Reviewed August 2010
What is the official name of the XIAP gene?
The official name of this gene is “X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase.”
XIAP is the gene's official symbol. The XIAP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the XIAP gene?
The XIAP gene provides instructions for making a protein that is found in many types of cells, including immune cells. It helps protect these cells from self-destructing (undergoing apoptosis) by blocking (inhibiting) the action of certain enzymes called caspases, which are necessary for apoptosis. Specifically, the XIAP protein inhibits caspase enzymes 3, 7, and 9. The XIAP protein also plays a role in several other signaling pathways that are involved in various functions in the body.
Does the XIAP gene share characteristics with other genes?
The XIAP gene belongs to a family of genes called BIRC (baculoviral IAP repeat-containing genes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the XIAP gene related to health conditions?
Where is the XIAP gene located?
Cytogenetic Location: Xq25
Molecular Location on the X chromosome: base pairs 123,859,812 to 123,913,979
The XIAP gene is located on the long (q) arm of the X chromosome at position 25.
More precisely, the XIAP gene is located from base pair 123,859,812 to base pair 123,913,979 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about XIAP?
You and your healthcare professional may find the following resources about XIAP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the XIAP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding XIAP?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.