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WRAP53

WRAP53

The information on this page was automatically extracted from online scientific databases.

What is the official name of the WRAP53 gene?

The official name of this gene is “WD repeat containing, antisense to TP53.”

WRAP53 is the gene's official symbol. The WRAP53 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the WRAP53 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

How are changes in the WRAP53 gene related to health conditions?

Genetics Home Reference provides information about dyskeratosis congenita, which is associated with changes in the WRAP53 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the WRAP53 gene's known or predicted involvement in human disease.

Dyskeratosis congenita, autosomal recessive, 3 (DKCB3): A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the WRAP53 gene.
  • Dyskeratosis congenita, autosomal recessive, 3
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the WRAP53 gene and its association with health conditions.
OMIM
Number
Title

Where is the WRAP53 gene located?

Cytogenetic Location: 17p13.1

Molecular Location on chromosome 17: base pairs 7,686,070 to 7,703,501

The WRAP53 gene is located on the short (p) arm of chromosome 17 at position 13.1.

The WRAP53 gene is located on the short (p) arm of chromosome 17 at position 13.1.

More precisely, the WRAP53 gene is located from base pair 7,686,070 to base pair 7,703,501 on chromosome 17.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about WRAP53?

You and your healthcare professional may find the following resources about WRAP53 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the WRAP53 gene or gene products?

  • DKCB3
  • TCAB1
  • WDR79

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding WRAP53?

anemia ; aplastic anemia ; autosomal ; autosomal recessive ; bone marrow ; chromosome ; DNA ; DNA damage ; fibrosis ; gene ; leukoplakia ; mRNA ; osteoporosis ; platelets ; protein ; pulmonary ; recessive ; reticulated ; splicing ; synthesis ; telomere ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 16, 2014