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Reviewed February 2008
What is the official name of the WNT3 gene?
The official name of this gene is “wingless-type MMTV integration site family member 3.”
WNT3 is the gene's official symbol. The WNT3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the WNT3 gene?
The WNT3 gene is part of a large family of WNT genes, which play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
Research in animals indicates that the protein produced from the WNT3 gene is critical for the outgrowth of the limbs in the developing embryo. The WNT3 protein also appears to play an important role in determining the anterior-posterior axis (the imaginary line that runs from head to tail in animals) during the earliest stages of embryonic development. Additionally, the effects of mutations in the human WNT3 gene suggest that the protein may be involved in the normal formation of the facial features, head, heart, lungs, nervous system, skeleton, and genitalia.
Does the WNT3 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the WNT3 gene related to health conditions?
Where is the WNT3 gene located?
Cytogenetic Location: 17q21
Molecular Location on chromosome 17: base pairs 46,762,506 to 46,818,760
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The WNT3 gene is located on the long (q) arm of chromosome 17 at position 21.
More precisely, the WNT3 gene is located from base pair 46,762,506 to base pair 46,818,760 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about WNT3?
You and your healthcare professional may find the following resources about WNT3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the WNT3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding WNT3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.