|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed April 2013
What is the official name of the WISP3 gene?
The official name of this gene is “WNT1 inducible signaling pathway protein 3.”
WISP3 is the gene's official symbol. The WISP3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the WISP3 gene?
The WISP3 gene provides instructions for making a protein that appears to be involved in bone growth and the maintenance of cartilage, which covers and protects the ends of bones. The function of the WISP3 protein is not well understood. It is part of a family of proteins that are involved in the growth and maintenance of connective tissues, such as bone, cartilage, and blood vessels. The WISP3 protein is made in cells called chondrocytes, which produce and maintain cartilage, and is associated with the production of certain proteins that make up cartilage, but its role in their production is unclear. WISP3 may also help control signaling pathways involved in the development of cartilage and bone and may help regulate the breakdown of cartilage components.
How are changes in the WISP3 gene related to health conditions?
Genetics Home Reference provides information about juvenile idiopathic arthritis, which is also associated with changes in the WISP3 gene.
Where is the WISP3 gene located?
Cytogenetic Location: 6q21
Molecular Location on chromosome 6: base pairs 112,053,516 to 112,069,686
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The WISP3 gene is located on the long (q) arm of chromosome 6 at position 21.
More precisely, the WISP3 gene is located from base pair 112,053,516 to base pair 112,069,686 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about WISP3?
You and your healthcare professional may find the following resources about WISP3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the WISP3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding WISP3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.