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WIPF1

WIPF1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the WIPF1 gene?

The official name of this gene is “WAS/WASL interacting protein family, member 1.”

WIPF1 is the gene's official symbol. The WIPF1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the WIPF1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.

How are changes in the WIPF1 gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the WIPF1 gene.
  • Wiskott-Aldrich syndrome 2
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the WIPF1 gene and its association with health conditions.
OMIM
Number
Title

Where is the WIPF1 gene located?

Cytogenetic Location: 2q31.1

Molecular Location on chromosome 2: base pairs 174,559,573 to 174,682,898

The WIPF1 gene is located on the long (q) arm of chromosome 2 at position 31.1.

The WIPF1 gene is located on the long (q) arm of chromosome 2 at position 31.1.

More precisely, the WIPF1 gene is located from base pair 174,559,573 to base pair 174,682,898 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about WIPF1?

You and your healthcare professional may find the following resources about WIPF1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the WIPF1 gene or gene products?

  • PRPL-2
  • WASPIP
  • WIP

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding WIPF1?

actin ; cell ; cell proliferation ; cytoskeleton ; eczema ; gene ; immunodeficiency ; intracellular ; proliferation ; protein ; recessive ; stress ; syndrome ; thrombocytopenia ; transcript ; virus ; X-linked recessive

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 16, 2014