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Reviewed December 2012
What is the official name of the VWF gene?
The official name of this gene is “von Willebrand factor.”
VWF is the gene's official symbol. The VWF gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the VWF gene?
The VWF gene provides instructions for making a blood clotting protein called von Willebrand factor. This protein contains regions that attach (bind) to specific cells and proteins during the formation of a blood clot. After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss.
Von Willebrand factor is made within endothelial cells, which line the inside surface of blood vessels, and bone marrow cells. The factor is made of several identical subunits. To facilitate binding to various cells and proteins, these subunits are cut into smaller pieces by an enzyme called ADAMTS13. Von Willebrand factor helps platelets stick together and adhere to the walls of blood vessels at the site of a wound. These groups of platelets form temporary clots, plugging holes in blood vessel walls to help stop bleeding. Von Willebrand factor also carries another blood clotting protein, coagulation factor VIII, to the area of clot formation.
Does the VWF gene share characteristics with other genes?
The VWF gene belongs to a family of genes called endogenous ligands (endogenous ligands).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the VWF gene related to health conditions?
Where is the VWF gene located?
Cytogenetic Location: 12p13.3
Molecular Location on chromosome 12: base pairs 5,948,874 to 6,124,670
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The VWF gene is located on the short (p) arm of chromosome 12 at position 13.3.
More precisely, the VWF gene is located from base pair 5,948,874 to base pair 6,124,670 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about VWF?
You and your healthcare professional may find the following resources about VWF helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the VWF gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding VWF?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.