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The information on this page was automatically extracted from online scientific databases.

What is the official name of the VPS35 gene?

The official name of this gene is “VPS35 retromer complex component.”

VPS35 is the gene's official symbol. The VPS35 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the VPS35 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

From UniProt (VPS35_HUMAN)This link leads to a site outside Genetics Home Reference.:

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).

How are changes in the VPS35 gene related to health conditions?

Genetics Home Reference provides information about Parkinson disease, which is associated with changes in the VPS35 gene.
UniProt (VPS35_HUMAN)This link leads to a site outside Genetics Home Reference. provides the following information about the VPS35 gene's known or predicted involvement in human disease.

Parkinson disease 17 (PARK17): An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the VPS35 gene.
  • Parkinson disease 17
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the VPS35 gene and its association with health conditions.

Where is the VPS35 gene located?

Cytogenetic Location: 16q12

Molecular Location on chromosome 16: base pairs 46,657,995 to 46,689,232

The VPS35 gene is located on the long (q) arm of chromosome 16 at position 12.

The VPS35 gene is located on the long (q) arm of chromosome 16 at position 12.

More precisely, the VPS35 gene is located from base pair 46,657,995 to base pair 46,689,232 on chromosome 16.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about VPS35?

You and your healthcare professional may find the following resources about VPS35 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the VPS35 gene or gene products?

  • MEM3
  • PARK17

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding VPS35?

autosomal ; autosomal dominant ; bradykinesia ; degradation ; domain ; endosomes ; enzyme ; gene ; immunoglobulin ; Lewy bodies ; plasma ; plasma membrane ; protein ; receptor ; spectrum ; substantia nigra ; TGN ; trans-Golgi network ; transmembrane ; tremor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: November 23, 2015