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Reviewed October 2009
What is the official name of the VLDLR gene?
The official name of this gene is “very low density lipoprotein receptor.”
VLDLR is the gene's official symbol. The VLDLR gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the VLDLR gene?
The VLDLR gene provides instructions for making a protein called a very low density lipoprotein (VLDL) receptor. This protein is active in many different organs and tissues, including the heart, muscles used for movement (skeletal muscles), fatty (adipose) tissue, and the kidneys. The VLDL receptor appears to play a particularly important role in the developing brain.
The VLDL receptor works together with a protein called reelin. Reelin fits into the VLDL receptor like a key in a lock, which triggers a series of chemical reactions within the cell. During early brain development, the reelin signaling pathway helps to guide the movement of immature nerve cells (neuroblasts) to their appropriate locations in the brain.
How are changes in the VLDLR gene related to health conditions?
Where is the VLDLR gene located?
Cytogenetic Location: 9p24
Molecular Location on chromosome 9: base pairs 2,621,678 to 2,656,099
The VLDLR gene is located on the short (p) arm of chromosome 9 at position 24.
More precisely, the VLDLR gene is located from base pair 2,621,678 to base pair 2,656,099 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about VLDLR?
You and your healthcare professional may find the following resources about VLDLR helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the VLDLR gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding VLDLR?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)