|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed January 2010
What is the official name of the VCAN gene?
The official name of this gene is “versican.”
VCAN is the gene's official symbol. The VCAN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the VCAN gene?
The VCAN gene provides instructions for making a protein called versican. Versican is a type of protein known as a proteoglycan, which means it has several sugar molecules attached to it. Versican is found in the extracellular matrix of many different tissues and organs. The extracellular matrix is the intricate lattice of proteins and other molecules that forms in the spaces between cells. Versican interacts with many proteins and molecules to facilitate the assembly of the extracellular matrix and ensure its stability. Within the eye, versican interacts with other proteins to maintain the structure and gel-like consistency of the thick clear fluid that fills the eyeball (the vitreous).
Researchers have proposed several additional functions for versican. This protein likely helps regulate cell growth and division, the attachment of cells to one another (cell adhesion), and cell movement (migration). Studies suggest that versican plays a role in forming new blood vessels (angiogenesis), wound healing, inflammation, and preventing the growth of cancerous tumors. Versican also regulates the activity of several growth factors, which control a diverse range of processes important for cell growth.
Four different versions (isoforms) of the versican protein are produced from the VCAN gene. These isoforms (called V0, V1, V2, and V3) vary by size and by their location within the body.
Does the VCAN gene share characteristics with other genes?
The VCAN gene belongs to a family of genes called proteoglycans (proteoglycans).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the VCAN gene related to health conditions?
Where is the VCAN gene located?
Cytogenetic Location: 5q14.3
Molecular Location on chromosome 5: base pairs 83,471,673 to 83,582,302
The VCAN gene is located on the long (q) arm of chromosome 5 at position 14.3.
More precisely, the VCAN gene is located from base pair 83,471,673 to base pair 83,582,302 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about VCAN?
You and your healthcare professional may find the following resources about VCAN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the VCAN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding VCAN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.