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Reviewed August 2012
What is the official name of the VAPB gene?
The official name of this gene is “VAMP (vesicle-associated membrane protein)-associated protein B and C.”
VAPB is the gene's official symbol. The VAPB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the VAPB gene?
The VAPB gene provides instructions for making a protein that is found in cells throughout the body. Little is known about the function of the VAPB protein. Research indicates that this protein is associated with the membrane that surrounds the endoplasmic reticulum, a specialized structure within cells. Among its many functions, the endoplasmic reticulum folds newly formed proteins and prepares them for transport within the cell or to the cell surface. To function efficiently, the endoplasmic reticulum relies on a system that detects a buildup of unfolded or misfolded proteins. The cell's process for preventing or correcting a buildup of abnormal proteins is called the unfolded protein response. Researchers suggest that the VAPB protein plays an important role in the unfolded protein response.
How are changes in the VAPB gene related to health conditions?
Where is the VAPB gene located?
Cytogenetic Location: 20q13.33
Molecular Location on chromosome 20: base pairs 56,964,174 to 57,026,156
The VAPB gene is located on the long (q) arm of chromosome 20 at position 13.33.
More precisely, the VAPB gene is located from base pair 56,964,174 to base pair 57,026,156 on chromosome 20.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about VAPB?
You and your healthcare professional may find the following resources about VAPB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the VAPB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding VAPB?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.