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UGT2B17

UGT2B17

The information on this page was automatically extracted from online scientific databases.

What is the official name of the UGT2B17 gene?

The official name of this gene is “UDP glucuronosyltransferase 2 family, polypeptide B17.”

UGT2B17 is the gene's official symbol. The UGT2B17 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the UGT2B17 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

How are changes in the UGT2B17 gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the UGT2B17 gene.
  • Bone mineral density quantitative trait locus 12[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the UGT2B17 gene located?

Cytogenetic Location: 4q13

Molecular Location on chromosome 4: base pairs 68,537,183 to 68,568,526

The UGT2B17 gene is located on the long (q) arm of chromosome 4 at position 13.

The UGT2B17 gene is located on the long (q) arm of chromosome 4 at position 13.

More precisely, the UGT2B17 gene is located from base pair 68,537,183 to base pair 68,568,526 on chromosome 4.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about UGT2B17?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the UGT2B17 gene or gene products?

  • BMND12
  • UDPGT2B17

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding UGT2B17?

bone mineral density ; conjugation ; copy number variation ; DHT ; dihydrotestosterone ; enzyme ; gene ; isozyme ; lipid ; locus ; metabolism ; mineral ; osteoporosis ; protein ; soluble ; steroids ; susceptibility ; testosterone ; toxic ; trait ; xenobiotics

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 21, 2014