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TYK2

TYK2

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TYK2 gene?

The official name of this gene is “tyrosine kinase 2.”

TYK2 is the gene's official symbol. The TYK2 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TYK2 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

How are changes in the TYK2 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the TYK2 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the TYK2 gene's known or predicted involvement in human disease.

Immunodeficiency 35 (IMD35): A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the TYK2 gene.
  • Tyrosine kinase 2 deficiency
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TYK2 gene and its association with health conditions.
OMIM
Number
Title

Where is the TYK2 gene located?

Cytogenetic Location: 19p13.2

Molecular Location on chromosome 19: base pairs 10,350,527 to 10,380,571

The TYK2 gene is located on the short (p) arm of chromosome 19 at position 13.2.

The TYK2 gene is located on the short (p) arm of chromosome 19 at position 13.2.

More precisely, the TYK2 gene is located from base pair 10,350,527 to base pair 10,380,571 on chromosome 19.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TYK2?

You and your healthcare professional may find the following resources about TYK2 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TYK2 gene or gene products?

  • IMD35
  • JTK1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TYK2?

cytokine ; deficiency ; domain ; gene ; IFN ; immunodeficiency ; immunoglobulin ; intracellular ; kinase ; mutation ; pneumonia ; protein ; receptor ; signal transduction ; syndrome ; transduction ; tyrosine

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 27, 2015